陈贵泉实验室

近五年发表论文列表(*, 通讯作者)：

1.    Bi H., Zhou C., Zhang Y., Cai X., Ji M., Yang J., Chen G.*, and Hu Y., Neuron specific deletion of Pen-2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling. In revision, 2020.

2.    Shao C., Yuan J., Liu Y., Qin Y., Wang X., Gu J., Chen G., Zhang B., Liu H., Zhao J., Zhu H., and Qian Y., Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis. Proc. Natl. Acad. Sci. USA, 2020. 117(19): p. 10155.

3.    Ma X., Wang Y., Hua J., Xu C., Yang T., Yuan J., Chen G.*, Guo Z., and Wang X., Abeta-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer's disease (Cover story). Sci.CHINAChem., 2020. 63(1): p. 73-82.

4.    Huang C., Liu T., Wang Q., Hou W., Zhou C., Song Z., Shi Y., Gao X., Chen G.*, Yin Z., and Hu Y., Loss of PP2A disrupts the retention of radial glial progenitors in the telencephalic niche to impair the generation for late-born neurons during cortical development (Cover story). Cere.b Cortex, 2020. 30: p. 4183-4196.

5.    Cheng S., Liu T., Hu Y., Xia Y., Hou J., Huang C., Zou X., Shi Y., Zheng Y., Lu J., and Chen G.*, Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors. J. Neurosci., 2019. 39: p. 2195-2207.

6.    Zhang T., Shi Z., Wang Y., Wang L., Zhang B., Chen G., Wan Q., and Chen L., Akt3 deletion in mice impairs spatial cognition and hippocampal CA1 long long-term potentiation through downregulation of mTOR. Acta Physiol., 2018. 225(1).

7.    Xu C., Yu L., Hou J., Jackson J., Wang H., Huang C., Liu T., Wang Q., Zou X., Morris R., Spires-Jones T., Yang Z., Yin Z., Xu Y., and Chen G.*, Conditional deletion of PDK1 in the forebrain causes neuron loss and increased apoptosis during cortical development. Front. Cell. Neurosci., 2017. 11: p. 330.

8.    Zhou J., Wang X., Zhou L., Zhou L., Xu F., Su L., Wang H., Jia F., Xu F., Chen G., De Zeeuw C., and Shen Y., Ablation of TFR1 in Purkinje cells inhibits mGlu1 trafficking and impairs motor coordination, but not autistic-like behaviors. J. Neurosci., 2017. 37: p. 11335-11352.

9.    Liu T., Ye X., Zhang J., Yu T., Cheng S., Zou X., Xu Y., Chen G.*, and Yin Z., Increased adult neurogenesis associated with reactive astrocytosis occurs prior to neuron loss in a mouse model of neurodegenerative disease. CNS Neurosci. Therap., 2017. 23(11): p. 885-893.

10.  He X., Li Y., Kalyanaraman C., Qiu L., Chen C., Xiao Q., Liu W., Zhang W., Yang J., Chen G., Jacobson M.P., and Shi Y.S., GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors. Proc. Natl. Acad. Sci. USA, 2016. 113(38): p. E5645-E5654.

11.  Wang L., Cheng S., Yin Z., Xu C., Lu S., Hou J., Yu T., Zhu X., Zou X., Peng Y., Xu Y., Yang Z., and Chen G.*, Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain. Mol. Neurodegener., 2015. 10: p. 33.

12.  Cheng S., Hou J., Zhang C., Xu C., Wang L., Zou X., Yu H., Shi Y., Yin Z., and Chen G.*, Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration. Sci. Rep., 2015. 5,10535; doi:10.1038.